Origin of Cancers: Gene-Centric Versus Cell-Centric

Origin of Cancers: Gene-Centric Versus Cell-Centric

The article by Gerlinger and colleagues (Mar. 8 issue) [1] is informative because it confirms what we already know. In the clinics, the genetic approach seems inadequate for us to solve the problem of tumor heterogeneity or reaching our goal of personalized care. However, we contend that the genetic approach is invaluable for our understanding of individual cancers and in our design of personal...

Knowledge versus Network Centric Warfare

Centric connectivity index by shell matrices

Relative centricity RC values of vertices/atoms are calculated within the Distance Detour and Cluj-Distance criteria on their corresponding Shell transforms. The vertex RC distribution in a molecular graph gives atom equivalence classes, useful in interpretation of NMR spectra. Timed by vertex valences, RC provides a new index, called Centric Connectivity CC, which can be useful in the topologi...

Network-Centric Warfare: Its Origin and Future

We are in the midst of a revolution in military affairs (RMA) unlike any seen since the Napoleonic Age, when France transformed warfare with the concept of levŽe en masse. Chief of Naval Operations Admiral Jay Johnson has called it "a fundamental shift from what we call platform-centric warfare to something we call network-centric warfare," and it will prove to be the most important RMA in the ...

From Process-Centric to Data Centric Replication